Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia (MCSAA)

Shengyun Lin

Status: Completed

Conditions: Aplastic Anemia

Treatments: Other: AA or not

Study type: Observational

Funder types: Other

Identifiers

NCT03208647

MCS-EDC-1802

Details and patient eligibility

About

To ascertain the risk factors of AA in ZheJiang Province of China at the moment, especially the comprehensive multiple factors risks. The author conducted a case-control research included 338 AA cases and 1464 controls. Subjects were surveyed using same standard questionnaire including personal data, past histories of diseases, family history and histories of occupational and daily exposure to harmful substances. Single and multiple Logistic regression analyses were made using SPSS17.0 on the dates to study potential factors in the development of AA.

Enrollment: 1,802 patients

Sex: All

Ages: 1 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All the patients of AA group met a AA diagnostic criteria；The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery;
• 1-65 years old, male or female;
• Sign the informed consent.

Exclusion criteria

• With myelodysplastic syndrome, leukaemia, multiple myeloma,megaloblastic anaemia, paroxysmal sleep hemoglobinuria disease blood disease, etc.
• History of tumor, radiation or chemotherapy, once accept the immunological therapy, autoimmune diseases or allergic disease patients;
• Patients with neurological diseases.

Trial design

1,802 participants in 2 patient groups

AA Group

Description:

All the patients of AA group met a AA diagnostic criteria；

Treatment:

Other: AA or not

Control Group

Description:

The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery;