A Study on Cardiopulmonary Exercise Tolerance Standards for Healthy Chinese Population (MCCS-CCPETS)

Affiliated Hospital of Changchun University of Chinese Medicine

Status: Not yet enrolling

Conditions: Cardiorespiratory Fitness; Oxygen Consumption

Treatments: Other: cardiopulmonary exercise testing (CPET)

Study type: Observational

Funder types: Other

Identifiers

NCT07108296

KFKT-2025-KY-010 (Other Grant/Funding Number)

Details and patient eligibility

About

This project intends to conduct a large-sample, prospective, multicenter clinical cohort study in healthy populations. By utilizing a digital cardiopulmonary rehabilitation clinical data research platform, The investigators aim to achieve automated, standardized, and uniform collection, analysis, and AI modeling of large-scale cardiopulmonary exercise testing (CPET) data. The ultimate goals are:

To establish reference standards for cardiopulmonary exercise capacity in the Chinese healthy population.

To develop machine learning-based predictive models for key CPET variables (e.g., peak VO₂) tailored to Chinese demographics.

To compare performance differences between domestically produced and imported CPET devices.

Enrollment: 4,620 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Detailed medical history taken, with no symptoms of discomfort reported
• Good physical condition, with no history of severe chronic diseases
• No history of long - term medication use
• Willing to undergo cardiopulmonary exercise testing, with no ST - T segment changes observed during the test
• Age: 18 - 65 years old
• BMI: 18.5 - 28kg/m²
• No smoking history or quit smoking for ≥5 years
• Physical examination reports within 2 years show no significant abnormalities.

Exclusion criteria

• Pre - test resting blood pressure ≥160/100 mmHg (1 mmHg=0.133 kPa)
• Chronic cardiovascular diseases, such as heart failure, coronary atherosclerotic heart disease, hypertension, congenital heart disease, cardiomyopathy, and severe arrhythmias
• Respiratory diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary artery hypertension, bronchiectasis, and respiratory failure
• Digestive system diseases, such as peptic ulcer, gastrointestinal bleeding, hepatitis, liver cirrhosis, ulcerative colitis, Crohn's disease, chronic pancreatitis, and chronic cholecystitis
• Endocrine system diseases, such as hyperthyroidism, hypothyroidism, diabetes, and other diseases with clear hormone abnormalities
• Acute or chronic kidney diseases, blood system diseases, malignant tumors, and bone and joint diseases that affect activity
• No history of acute infection within 2 weeks
• Unable to cooperate with the examination
• Contraindications to cardiopulmonary exercise testing: acute myocardial infarction

Trial design

4,620 participants in 1 patient group

Chinese Age-Sex-Stratified Cardiopulmonary Function Cohort (CACSF Cohort)

Treatment:

Other: cardiopulmonary exercise testing (CPET)