Status and phase
Conditions
Treatments
About
This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms.
Full description
MHS-1031 is a specific proprietary digestion-resistant oligosaccharide carbohydrate that serves as a prebiotic.
This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 adjunctive to PPI therapy on heartburn-free days in subjects with GERD-related heartburn symptoms who self-report improvement while on sustained daily PPI therapy. Heartburn-free days will be determined by subject report specific to any of the three questions ("burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn"; Questions 1, 2 & 3 of the RESQ-eD). For purposes of this trial, heartburn-free days are defined as subject report of 'Did Not Have', or 'Very Mild' on each of the three RESQ-eD questions listed above.
All candidate subjects must self-report at least partial response to sustained daily PPI acid suppressive therapy (i.e. 'daily' defined as taking PPIs 5-7 days/week on average). Candidate subjects will be screened for medical history of chronic heartburn that may be associated with other medical conditions, and these subjects will be excluded. The entire study consists of three phases: Remote Screening Phase 2-Week Assessment (SP1), on-site Screening Phase Part 2 (SP2) and Treatment Phase (TP).
Efficacy will be assessed using patient reported outcome (PRO) questionnaires, concomitant medication assessments, and assessment of adverse events, from baseline (determined during Remote Screening Phase 2-Week Assessment) to Treatment Phase Weeks 1-4 and Weeks 5-8. The primary analyses will be conducted to assess the efficacy of MHS-1031 adjunctive to PPI therapy, and separately as monotherapy subsequent to combined PPI and MHS-1031 therapy, in randomized subjects with GERD-related heartburn as determined by the RESQ-eD validated questionnaire, validated for use online.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
Current use of any mouthwash (e.g., Listerine, Scope, others) or unwilling to discontinue use for the duration of the study (requires 3-day washout prior to starting the Remote Screening Phase 2-Week Assessment)
Teeth whitening within 7 days of Screening Call or current use of teeth whitening substances (not including teeth whitening toothpaste) or unwilling to discontinue use for the duration of the study (requires 7-day washout prior to starting the Remote Screening Phase 2-Week Assessment).
Current use of histamine 2 receptor antagonists (H2RAs) (requires 7-day washout prior to starting the Remote Screening Phase 2-Week Assessment).
Surgical procedure requiring general anesthesia within 60 days of the Screening Call
Colonoscopy, high colonic, colonic cleanse or barium enema in the past 30 days, or scheduled for colonoscopy or barium enema at any time for the duration of the study, and unwilling to postpone until after study completion.
History of cancer diagnosis and/or treatment (other than basal cell carcinoma of the skin) within the preceding five (5) years.
Concomitant illness with potential to confound outcome assessments for this study, including, but not limited to:
Acute or chronic hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection.
Significant current morbidity of the heart, kidney, liver or lung.
History of Long QT Syndrome
History of Torsades de pointes (TdP)
Current neurological or psychiatric disorder (e.g., Parkinson's, Huntington's chorea, schizophrenia, seizure, bi-polar disorder, major depressive disorder).
Known or suspected alcoholism, drug addiction, or significant drug abuse within 1 year of the Screening Call based on subject reporting and PI assessment.
Active history of tobacco or nicotine use (of any type) in the last 6 months averaging more than 1 cigar/cigarette per week. Vaping products and e-cigarettes that contain nicotine and/or tobacco are not allowed. Chewing tobacco and nicotine gum are prohibited at any level. Nicotine patches are NOT exclusionary.
Alcohol abuse (for alcohol defined as: > 14 drinks/week or 4 drinks/day for men, 7 drinks/week or 3 drinks/day for women).
Intake of acetylsalicylic acid (i.e., aspirin) at doses > 162 mg/day.
Non-steroidal anti-inflammatory pain relievers (NSAIDs) such as ibuprofen (Advil®, Motrin® IB, others) >/= 4 days/week on average not to exceed half the recommended maximum prescription daily dosing as listed in the Physician's Desk Reference.
Acetaminophen > 2,000 mg/day
Inhalation or ingestion of products containing delta-9-tetrahydrocannabinol (THC) > 2 days/week on average.
Any known medical condition, clinical signs and symptoms, vital signs, abnormal laboratory, or other testing that are not well controlled on stable dosing of medication for at least 90 days prior to the Screening Call or are considered clinically significant by the Principal Investigator (PI), that could interfere with the subject's participation in and completion of the study. Examples of medical conditions including, but not limited to:
Uncontrolled hypertension
Uncontrolled diabetes
History of adrenal disease, diabetic nephropathy, or gastroparesis
Uncontrolled hypothyroidism
Untreated mental disorder
Paraplegia or Quadriplegia
Cerebrovascular event (stroke) or myocardial infarction (MI) within the last 6 months.
Structural abnormality of the GI tract, or disease or condition that can affect GI motility (e.g., achalasia, esophageal atresia), or defecation.
Planned travel outside the US during the study period or routine travel within the US during the study period that results in >2-hour time zone difference.
Cyclical work shift (e.g., routinely switching between day shifts and night shifts)
Any of the following current (within the past 6 months) symptomatic conditions:
History of ischemic colitis in the past 5 years.
Current COVID19 infection, or a history of a prior COVID19 infection with ongoing symptoms suggestive of "Long COVID".
Endoscopic evidence of any of the following:
History of fecal impaction that required hospitalization or emergency room treatment within 3 months of the Screening Call.
History of eating disorder within the last 2 years.
Symptomatic condition (e.g., polycystic kidney disease, endometriosis, ovarian cysts, etc.) during the 12 months prior to the Screening Call that required intervention (i.e., clinic or emergency room visit or hospitalization) that may be associated with chronic abdominal pain or discomfort and might confound the assessments in this study.
Surgical history that meets any of the following criteria:
Gastric bypass surgery or invasive procedure for the treatment of obesity or surgery to remove a segment of the GI tract at any time prior to the Screening Call
Gastric band present within the past 60 days
Open surgery of the abdomen, pelvis, or retroperitoneal structures within 6 months prior to the Screening Call
Laparoscopic appendectomy or cholecystectomy or other instrumentation of the bowel < 60 days prior to the Screening Call. NOTE: Endoscopic removal of benign polyps is not exclusionary.
Prior use of the study medication MHS-1031 or ISOThrive Prebiotic Nectar.
Use of fructo-oligosaccharides (FOS) or inulin.
Symptomatic condition (e.g., angina, rumination, or other conditions involving the mouth and/or throat) during the 12 months prior to the Screening Call.
Use of any of the following medications that have not been stable dosing for at least 90 days at time of Screening Call:
Use of Nitrates within the last 12 months.
Medication for depression, anxiety, or sleep (e.g., benzodiazepines such as diazepam (Valium®) and temazepam (Restoril) with uncontrolled symptoms or medication dosing that has not been stable for at least 90 days at time of Screening Call.
Antibiotic use within 60 days of the Screening Call.
Narcotic (e.g., opiate) or illicit drug (i.e., illegal at both the Federal and State levels; e.g. Cocaine, Heroin, Methamphetamine) use within 60 days of the Screening Call.
Use of any investigational product within 90 days prior to the Screening Call.
Use of GLP-1 agonists (e.g., Dulaglutide (Trulicity), Exenatide, Semaglutide (Ozempic/Wegovy), Liraglutide) or prescription medications used for weight loss within 6 months of Screening Call.
Pregnancy, lactation, planned pregnancy or planned ova donation during the study period.
Participation in another investigation (clinical trial) during the course of this study.
Any major lifestyle change, such as getting married, change in residence, change in job, or other highly stressful event planned during the study periods.
Sustained daily use of PPIs without self-report of improvement of heartburn symptoms.
Self or relative employed directly or indirectly by the Sponsor or relative or employee of investigator or investigator's staff.
Other conditions or situations that, in the Investigator's opinion, may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study.
Primary purpose
Allocation
Interventional model
Masking
156 participants in 2 patient groups, including a placebo group
Loading...
Central trial contact
Tina Higginbotham
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal