Multi-institutional Analysis of Survival and Recurrence Patterns of Different Pathological Regression Types After Neoadjuvant Chemoradiotherapy or Radiotherapy for Esophageal Squamous Cell Carcinoma

Tianjin Medical University

Status: Completed

Conditions: Esophageal Squamous Cell Carcinoma

Treatments: Other: non-intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06241079

bc2023183

Details and patient eligibility

About

The goal of this multicenter retrospective cohort study is to evaluate the impact of different pathological regression types on survival and recurrence patterns, with a particular focus on ypT0N+ patients in patients with esophageal squamous cell carcinoma. The main questions it aims to answer are the survival and recurrence patterns among the different pathological regression types in patients with esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy.

Enrollment: 582 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed potentially resectable ESCC, clinical stage T1-4N0-1M0 (stage I-III) according to the American Joint Committee on Cancer 6th edition staging criteria.

Exclusion criteria

• incomplete surgical resection, two-dimensional radiotherapy, and incomplete clinical data.

Trial design

582 participants in 4 patient groups

ypT0N0

Treatment:

Other: non-intervention

ypT0N+

Treatment:

Other: non-intervention

ypT+N0

Treatment:

Other: non-intervention

ypT+N+

Treatment:

Other: non-intervention