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Multi-model Image of Doxycycline in TAO

Sun Yat-sen University logo

Sun Yat-sen University

Status

Enrolling

Conditions

Thyroid Associated Ophthalmopathy

Treatments

Drug: Doxycycline Hyclate

Study type

Interventional

Funder types

Other

Identifiers

NCT05112211
TAODOXYIMAGE

Details and patient eligibility

About

This study aims to evaluate the efficacy of doxycycline treating Thyroid Associated Ophthalmopathy by multi-modal image.

Full description

Thyroid Associated Ophthalmopathy is one of autoimmune orbital diseases characterized by enlargement of the extraocular muscles and increase in fatty or/and orbit connective tissue volume affecting the appearance and visual function of the eyes. Different degrees of exophthalmos, eyelid aperture, lid retraction and lid lag are common symptoms apprearing in TAO. The improvement of exophthalmos is usually measured with Hertel instrument and the change of eyelid is measured with millimeter ruler. All these measurements are subjective, low reliable and less accurate.

TAO can be classified into active phase and inactive phase according to the activity score and wait-and-see or surgery are widely chosen for patients in inactive phase. But still a progression and reoccurrence can be a big challenge for ophthalmologists. This is a perspective cohort study to evaluate the efficacy of doxycycline in TAO by multi-model image.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Informed consent
  • Age 18-70 years old
  • Diagnosed with TAO

Exclusion criteria

  • Sight-threatening TAO with dysthyroid optic neuropathy
  • Allergy of tetracycline
  • Have contraindications of MRI(metal pacemaker, fake teeth, foreign body and other materials which will disturb the examination)

Trial design

Primary purpose

Screening

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

doxycycline
Experimental group
Description:
patients administrated with doxycycline tablets 100mg orally per day
Treatment:
Drug: Doxycycline Hyclate

Trial contacts and locations

1

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Central trial contact

Dan Liang; Yuxi Chen

Data sourced from clinicaltrials.gov

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