Multi-model Image of Immunosuppressive Agents in TAO

Sun Yat-sen University

Status

Enrolling

Conditions

Thyroid Associated Ophthalmopathy

Treatments

Drug: immunosuppressive agent

Study type

Interventional

Funder types

Other

Identifiers

NCT05110040

TAOIMTIMAGE

Details and patient eligibility

About

This study aims to evaluate the efficacy of immunosuppressive agents treating Thyroid Associated Ophthalmopathy by multi-model image.

Full description

Thyroid Associated Ophthalmopathy is one of autoimmune orbital diseases characterized by enlargement of the extraocular muscles and increase in fatty or/and orbit connective tissue volume affecting the appearance and visual function of the eyes. TAO can be classified into active phase and inactive phase according to the activity score and wait-and-see or surgery are widely chosen for patients in inactive phase. A great number of patients in inactive phase becoming refractory and reoccurring.

Until now, the improvement of TAO is still be measured subjectively with low reliability and less accuracy. Multi-modal image is a new method to assess both the appearance and visual function of TAO and some of the indexes can be regarded as more apparent and stable in assessing the efficacy and prognosis of TAO.

This perspective cohort study aims to evaluate the efficacy of immunosuppressive agents in TAO by multi-model image and function assessments.

Enrollment

12 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Informed consent
Age 18-70 years old
Diagnosed with TAO.

Exclusion criteria

Contraindications to immunosuppressive agents.
Patients with HIV, Hepatitis B or C, Tuberculosis or other active significant infection.
Patients with severe chronic diseases in heart, lung, kidney and liver, which make it not tolerant to immunosuppressive agents.
Patients have contraindications of MRI(metal pacemaker, fake teeth, foreign body and other materials which will disturb the examination).