Multi-Nutrient Supplement for Radio-Protection (MNSRP)

McMaster University

Status and phase

Not yet enrolling

Early Phase 1

Conditions

DNA Damage, Radiation Induced

Oxidative Stress

Radiation Exposure

Treatments

Drug: Placebo

Drug: Multi-nutrient supplement

Study type

Interventional

Funder types

Other

Identifiers

NCT04781868

13032

Details and patient eligibility

About

Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells. While the amount of DNA damage that may occur from one scan is not harmful to your overall health, there could be concerning damage in patients who are constantly exposed to this radiation. Currently, there is no way to prevent DNA damage during a medical scan. One potential way to fight the oxidative stress caused by radiation is to take an antioxidant before a scan. The purpose of this study is to see if a combination of antioxidants can protect someone from the damage that radiation causes to the DNA of their white blood cells.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 74 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18 to 76 years.
Scheduled for bone scan procedure at the Juravinski Hospital.

Exclusion criteria

History of smoking within six months prior to study enrollment.
Known hypersensitivity reactions to any of the ingredients in the MNSRP.
Chemotherapy or radiation therapy within six months prior or one month following study enrollment.
Individuals currently taking vitamin or mineral supplements that contain antioxidants will be considered on a case-by-case basis but will be asked to refrain from intake for at least two weeks prior to partaking in this study.