Multi-omics Analysis of Chronic Kidney Disease

Tongji University

Status: Enrolling

Conditions: Potential Mechanisms Underlying the Microbiota-Gut-Kidney Axis in CKD

Treatments: Behavioral: renal function

Study type: Observational

Funder types: Other

Identifiers

NCT05543291

SHYS-IEC-5.0/22K162/P01

Details and patient eligibility

About

Chronic kidney disease (CKD) is a progressive disease with hidden epidemics and one of the most significant contributing factors to end-stage renal disease (ESRD), cardiovascular comorbidities, cachexia and anemia, which accounts for a nearly 1.2 million populations died per year.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Age-matched and gender-matched HC with normal renal and liver function and not taking any medications were enrolled

Exclusion criteria

1. Age<18 years.
2. Individuals with hypertension, diabetes, obesity, metabolic syndrome or pregnancy.
3. Individuals who received gastrointestinal operation, antibiotics or probiotic products within one month.

Trial design

150 participants in 4 patient groups

healthy controls

Treatment:

Behavioral: renal function

mild CKD

Treatment:

Behavioral: renal function

Moderate CKD

Treatment:

Behavioral: renal function

ESRD

Treatment:

Behavioral: renal function