Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

Dan Bing

Status

Not yet enrolling

Conditions

Hearing Loss, Sudden

Sudden Sensorineural Hearing Loss

Hearing Loss, Sensorineural

Study type

Observational

Funder types

Other

Identifiers

NCT06365775

TJ-IRB20221229

Details and patient eligibility

About

The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL). The main problems it aims to deal with are:

if there is a difference in data of exome and targeted sequencing among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls
if there is a difference in the parameter of MRI among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls
to find out which factor from multi-omics data relates to outcomes of SSNHL
to develop the best prognostics model based on the multi-omics data.

Participants will be received audiological tests, blood specimen collection and radiological examination. Researchers will explore the relationship between the multi-omics data and the prognosis and develop the predictive model.

Enrollment

400 estimated patients

Sex

All

Ages

4 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age ≥ 4
Participants with SSNHL: unilateral or bilateral sensorineural hearing loss of > 30 dB HL (decibel) involving at least 3 continuous test frequencies developing within 72 hours
Healthy controls: people with PTA thresholds of all test frequencies ≤ 20 dB HL and without otologic disease in the last 3 months
Completed informed consent and promised to finish follow-ups

Exclusion criteria

Hearing loss with explicit causes, including noise-induced, Ménière's disease, ototoxicity exposure, mumps infection or history of syphilis infection and so on.
A history of head trauma or otologic surgery.
Malformation of temporal bone discovered by computed tomography (CT)
Retro-cochlear lesion discovered by magnetic resonance imaging (MRI)
Pregnant women