Multicenter Cohort Study of ESD and Chemo-radiotherapy for High-risk Early-stage Esophageal Cancer (ESCORT)

Zhejiang University

Status: Enrolling

Conditions: Esophagus Cancer

Treatments: Radiation: chemo-radiation

Study type: Observational

Funder types: Other

Identifiers

NCT06385717

ZhejiangU

Details and patient eligibility

About

This multicenter, prospective observational cohort study has the potential to optimize individualized chemoradiotherapy regimen for early-stage esophageal cancer patients who have received endoscopic submucosal dissection.

Full description

Our study can further improve the local-regional lymph nodes control rate and alleviate the toxicity of chemoradiotherapy.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Esophageal cancer patients who are pathologically confirmed as pT1a-MM stage or pT1b stage after endoscopic submucosal dissection； 2. No definite contraindications for chemo-radiotherapy； 3. Informed consent has been signed； 4. Refused surgery after endoscopic submucosal dissection.

Exclusion criteria

• 1. Severe heart, brain, lung disease or renal dysfunction; 2. Previous history of other malignancies; 3. Prior radiation or chemotherapy 4. Researchers consider it inappropriate to participate in this experiment

Trial design

120 participants in 3 patient groups

Prophylactic chemoradiotherapy

Description:

pT1a -MM and pT1b-SM1 without pathological risk factors

Treatment:

Radiation: chemo-radiation

Intensive chemoradiotherapy

Description:

pT1b-SM2; pT1a -MM and pT1b-SM1 with pathological risk factors

Treatment:

Radiation: chemo-radiation

Radical chemoradiotherapy

Description:

Positive vertical margin or unknown margin

Treatment:

Radiation: chemo-radiation