Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression (CORVAD)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Major Depression

Study type: Observational

Funder types: Other

Identifiers

NCT02171923

P110139

Details and patient eligibility

About

To examine whether the medial prefrontal cortex displays an increased activity during self-referential processing among remitted depressed patients compared to healthy controls

Enrollment: 77 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria (patients)

• History of at least one major depressive episode
• In clinical remission for at least 6 months (BDI-21 ≤ 10 & Montgomery and Asberg Depression Rating Scale ≤ 7)
• Aged 20-65

Exclusion criteria :

• first depressive episode after the age of 59
• last episode treated by cognitive behavior therapy
• currently receiving a antipsychotic or mood-stabilizing drug
• personal history of: major depressive episode with psychotic features, other axis-I disorder (except generalized anxiety disorder), substance-related disorder (except nicotine dependence), bipolar disorder
• first-degree familial history of bipolar disorder
• cognitive impairment due to another central nervous system disease
• contra-indication to MRI
• pregnancy
• refusal to be informed of abnormal findings during the MRI

Trial design

77 participants in 2 patient groups

Remitted depressed patients

Description:

Formerly depressed patients in remission for 6 months or more

healthy controls

Description:

healthy subjects with no history of mental disorders