Multicenter Retrospective Study on Patients Treated with Stereotactic Radiosurgery/Radiotherapy for Single Brain Lesions: Evaluation of Treatment Efficacy and Safety, Also Through Radiomic Analysis Methods. (STEREOMIC)

Gemelli Molise Hospital

Status: Active, not recruiting

Conditions: Radiotherapy Side Effect; Brain Metastases

Treatments: Radiation: Stereotactic Body Radiotherapy/Radiosurgery

Study type: Observational

Funder types: Other

Identifiers

NCT06869460

CET20-02-2024

Details and patient eligibility

About

The study design concerns all patients diagnosed witha singular brain metastasis who underwent stereotactic radiosurgery/radiotherapy between January 2010 and December 2022

Full description

The study will include patients of both sexes diagnosed with single brain metastases who underwent radiosurgical/stereotactic treatment. Attention will be paid to data related to local control, potential recurrence, and/or radionecrosis. Once a sufficient number of treated patients is reached, the feasibility of a radiomic feature analysis will be assessed in order to identify potential correlations and/or predictive values for treatment response or radionecrosis. If the sample size is adequate, participating centers will be asked to share pre- and post-RT MRI (brain MRI with contrast using thin slices) and treatment volumes for radiomic evaluation.

Enrollment: 372 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Treatment with SRS/SRT techniques for a single secondary brain lesion
• Availability of pre-RT brain MRI with contrast (1mm slice thickness)
• Availability of CT simulation imaging for treatment
• Availability of relevant clinical data in the medical record for the study's objectives
• Follow-up of at least 6 months after the completion of SRS or SRT
• Follow-up evaluation through brain MRI

Exclusion criteria

• Age under 18 years
• Lack of clinical/radiological data for the patient
• Unavailability of the required imaging
• Previous whole-brain radiotherapy treatment

Trial design

372 participants in 1 patient group

Patients with a singular brain metastases

Description:

The study design concerns all patients diagnosed with brain metastases who underwent stereotactic radiosurgery/radiotherapy between January 2010 and December 2022

Treatment:

Radiation: Stereotactic Body Radiotherapy/Radiosurgery