Multicenter Study of Impulse Oscillometry in Chinese

Guangzhou Institute of Respiratory Disease

Status: Unknown

Conditions: Asthma; Chronic Obstructive Pulmonary Disease; Healthy Subjects; Upper Airway Obstruction; Interstitial Lung Disease

Treatments: Other: Clinical Observation

Study type: Observational

Funder types: Other

Identifiers

NCT03467880

GIRD201536

Details and patient eligibility

About

The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), and upper airway Obstruction (UAO).

Enrollment: 4,000 estimated patients

Sex: All

Ages: 4 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for healthy subjects:

• life-long non-smokers
• no symptoms and history of chronic cardiopulmonary diseases (chronic bronchitis, asthma, lung cancer, pulmonary fibrosis, pulmonary tuberculosis, chronic heart diseases, etc.)
• no abnormal findings on physical examination
• written informed consent was obtained

Inclusion Criteria for COPD:

• Diagnosis of chronic obstructive pulmonary disease (COPD), as classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and post-bronchodilator FEV1/FVC (forced vital capacity) < 70%.

Inclusion Criteria for asthma:

• Diagnosis of asthma, as classified by national and international asthma guidelines.

Inclusion Criteria for ILD:

• ILD diagnosis confirmed by lung biopsy, X ray or BALF analysis.

Inclusion Criteria for UAO:

• Diagnosis of UAO.

Exclusion Criteria for healthy subjects:

• upper or lower respiratory infection within 4 weeks
• long-term exposure to harmful gas or particles
• using β-blocker for treatment
• pregnant women, epileptic
• other diseases or surgeries potentially affecting lung function

Trial design

4,000 participants in 5 patient groups

Healthy subjects

Description:

Healthy subjects.

Treatment:

Other: Clinical Observation

Chronic obstructive pulmonary disease

Description:

Patience with chronic obstructive pulmonary disease.

Treatment:

Other: Clinical Observation

Asthma

Description:

Patience with asthma.

Treatment:

Other: Clinical Observation

Interstitial lung disease

Description:

Patience with interstitial lung disease.

Treatment:

Other: Clinical Observation

Upper airway obstruction

Description:

Patience with upper airway obstruction.

Treatment:

Other: Clinical Observation