Multicenter Study on Detection Strategy of Infectious Diseases in Blood Transfusion

Central South University

Status

Unknown

Conditions

Infectious Disease Screening

Treatments

Diagnostic Test: infectious disease screening

Study type

Observational

Funder types

Other

Identifiers

NCT04471688

ThirdXiangyaMSID

Details and patient eligibility

About

In the past ten years, nucleic acid detection technology has overcome the limitations of serological detection, reduced missed detections due to window period, occult infection, etc., and its application in the field of pathogen detection has developed rapidly. Since 2015, domestic blood collection and supply institutions have fully popularized nucleic acid testing. The safety screening of blood sources mostly adopts the method of combining two times of enzyme-free negative and one time of nucleic acid testing, which excludes the guarantee of blood safety to the greatest extent.

At present, the clinical pre-transfusion and pre-operative infectious disease screening in our country is still serological detection. The use of nucleic acid detection for infectious disease screening can better realize the significance of patients' pre-transfusion/pre-operative infectious disease screening. Therefore, this study will analyze the nucleic acid detection technology and clinical serological detection technology in order to solve three problems:

Explore the best detection strategy for patients with pre-transfusion/pre-operative infectious disease screening; ② Explore the confirmation process of the gray area results of infectious disease serological testing; ③ Better realize the significance of screening for patients' infectious diseases.

Enrollment

10,000 estimated patients

Sex

All

Ages

1 to 100 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria