Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types (FAPIDO)

Catholic University (KU) of Leuven

Status and phase

Enrolling

Phase 3

Phase 2

Conditions

Oesophageal Cancer

FAP

Oncology

Gastric Cancer

Pancreatic Ductal Adenocarcinoma

Oncologic Disorders

Treatments

Diagnostic Test: [18F]AlF-FAPI-74 PET/CT

Study type

Interventional

Funder types

Other

Identifiers

NCT06782412

2024-512059-19 (EudraCT Number)

S67792

Details and patient eligibility

About

The aim of the project is to demonstrate superior detection ratio of [18F]AlF-FAPI-74 PET/CT compared to [18F]FDG PET/CT or conventional imaging in treatment-naïve, newly diagnosed patients with oesophagogastric adenocarcinoma (clinical T1-4N0-3M0) and pancreatic ductal adenocarcinoma (clinical T1-4N0-2M0-1) and describe the clinical utility of [18F]AlF-FAPI-74 PET/CT in oncological patients with a clinically challenging situation.

Enrollment

109 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria OGA:

Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.
Age 18 or older.
New histologic or cytologic proven diagnosis of oesophagogastric adenocarcinoma.
Patient underwent a [18F]FDG PET/CT.
TNM classification: cT1-4N0-3M0

Inclusion Criteria PDAC:

Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.
Age 18 or older.
New histologic or cytologic proven diagnosis of pancreatic ductal adenocarcinoma.
Patient underwent a [18F]FDG PET/CT or conventional staging with CT or MRI.
TNM classification: cT1-4N0-2M0-1, with the exception of upfront resectable patients.

Inclusion Criteria Clinically challenging cohort:

Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.
Age 18 or older.
Histologic or cytologic proven diagnosis of a malignancy.
Patient underwent a [18F]FDG PET/CT.
Unexplained symptoms, complaints, biochemical or imaging (scintigraphy, PET, CT, MR) findings.

Exclusion Criteria:

Participant is mentally or legally incapacitated, doesn't understand the study design or is not willing or capable to undergo all study-specific procedures.
Any disorder or condition, which in the Investigator's opinion might jeopardise the participant's safety or compliance with the protocol.
Any prior or concomitant treatment(s) that might jeopardise the participant's safety or that would compromise the integrity of the Trial.
Female who is pregnant (urinary hCG test can be performed in case of doubt), breast-feeding or intends to become pregnant or is of child-bearing potential and not using an adequate, highly effective contraceptive (with a relatively high Pearl Index: natural methods, minipill outside postpartum period, spermicides or condoms in monotherapy or no usage of contraception when sexually active are not accepted).
Participation in an interventional Trial with an investigational medicinal product (IMP) or device when the trial designs are not considered compatible by the study team.
Participation in a clinical scientific study in the last 12 months with a radiation exposure caused by the experimental procedures greater than 1 mSv.
Participant has a known hypersensitivity to [18F]AlF-FAPI-74 or the used excipients.