Multicentric Open-label Study of Switch From Abacavir/Lamivudine Fixed Dose Combination Plus Nevirapine to Abacavir/Lamivudine/Dolutegravir in Virologically Suppressed HIV-1 Infected Adults (SWAD)

Nantes University Hospital (NUH)

Status and phase

Completed

Phase 2

Conditions

HIV-1 Infection

Treatments

Drug: Abacavir/Lamivudine/Dolutegravir

Study type

Interventional

Funder types

Other

Identifiers

NCT02067767

RC13_0230

Details and patient eligibility

About

Abacavir/Lamivudine + Nevirapine (ABC/3TC + NVP) is a very effective and well tolerable regimen on the long-term. However this regimen comprises 2 pills per day. Abacavir/Lamivudine/Dolutegravir (ABC/3TC/DTG) offers simplification with a single pill per day with no food constraints, Dolutegravir (DTG) having the advantage over Nevirapine (NVP) of high potency, higher genetic barrier to resistance, with a very good safety profile. The objective of this study is to evaluate the virologic safety (maintenance of virologic suppression) after switching from ABC/3TC + NVP to ABC/3TC/DTG in 50 HIV-1 infected adults with prolonged HIV RNA suppression on ABC/3TC + NVP, as well as clinical and laboratory safety. Because nevirapine is a strong inducer of hepatic enzymes, pharmacocinetic (PK) assessment will be performed in all patients in the first weeks after switch and 24-hours PK in a subset of 10 patients after 5 days of DTG addition to current regimen, before switching to ABC/3TC/DTG.

Enrollment

53 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient with confirmed HIV-1 infection (HIV antibody positive confirmation prior to screening)
Age ≥ 18 years
Written informed consent
Male patient or non-pregnant, non-lactating female patient
On antiretroviral treatment with nevirapine (400 mg per day) plus abacavir/lamivudine for more than 6 months; Nevirapine 400 mg/day being administered as either 1 x 200 mg IR x 2/day or 2 x 200 mg IR qd or 1 x 400 mg XR qd
No history of prior virologic failure on antiretroviral therapy
HIV-1 RNA < 50 copies/ml for more than 1 year,
No major IAS-USA nucleoside reverse transcriptase inhibitors or integrase inhibitors resistance mutations on genotypic testing on last plasma sample with HIV-1 RNA > 500 c/mL (if available)
HLA-B*5701 negative test
Subjects covered by Health Insurance

Exclusion criteria

Woman of child-bearing potential without effective contraception method. Pregnant or breastfeeding woman.
Woman expecting to conceive during the study period
HIV-2 co-infection
Any prior exposure to integrase inhibitor(s)
Plasma HIV-1 RNA > 50 c/mL in the past year
Creatinine clearance < 60 ml/mn (estimated glomerular filtration rate according to the MDRD equation),
Alkaline phosphatase, ASAT or ALAT ≥ 5 times the upper limit of the norm (ULN)
Patient with history of decompensated liver disease
Any major IAS-USA mutation conferring resistance to one or more of reverse transcriptase or integrase inhibitors on any historical plasma genotype if available. Any previous genotype result is valid, with no time limit, as long as the original test result is documented.
Mycobacteriosis under treatment
Malignancy requiring chemotherapy or radiotherapy
Positive HBs Ag
HCV infection for which specific treatment is ongoing or planned during the study
Known hypersensitivity to one of the trial drugs, the metabolites or formulation excipients
Concomitant therapy with antacids or H2 antagonists
Contraindicated concomitant treatment
Anticipated non-compliance with the protocol
Participation in another clinical trial with an on-going exclusion period at screening
Subject under legal guardianship or incapacitation
Subject, who in the opinion of the investigator, is unable to complete the study period