Multicountry Studies on the Effect of Positional Distribution of Fatty Acids at Triglyceride Backbone on Serum Lipids, Lipoprotein(a) and LDL-subclasses in Healthy Malaysian Volunteers (MC1)

Malaysia Palm Oil Board

Status: Completed

Conditions: Cardiovascular Risk Factor

Treatments: Other: Diet: Palm olein IV64; Other: Diet: Virgin olive oil; Other: Diet: Cocoa butter

Study type: Interventional

Funder types: Other

Identifiers

NCT02802904

PD205/15- STUDY 1 (A)

Details and patient eligibility

About

Fats and oils are made up of >90% triacylglycerol fat molecules which consist of a glycerol backbone to which 3 esterified fatty acids are attached. The positions of fatty acid attachment are referred to by stereospecific numbers, sn -1, -2 and -3. There is existing evidence to show that vegetable oils having unsaturated fatty acids in the sn-2 position with predominantly palmitic acid (16:0) or stearic acid (18:0) in the sn-1 and sn-3 positions of fat molecules do not raise serum cholesterol levels. These observations have come to be known as or explained by the "sn-2 hypothesis". New evidence have also emerged to show that saturated fatty acids (16:0, 18:0) in the sn-1 and -3 positions reduces fat deposition in a rat model. In this proposed study, the effects on the outcome measures investigated of three test fats [namely palm olein IV64 (POP), virgin olive oil (OOO) and cocoa butter (POS)], with oleic acid primarily at the sn-2 position but differing amounts of palmitic, stearic and oleic acids at the sn-1/sn-3 positions of the triglyceride molecule, are investigated

Full description

To investigate the effects of different dietary fats with primarily oleic acid in the sn-2 position on the cardiovascular risk profile in healthy Malaysian volunteers

Enrollment: 42 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult male or female, aged 20-50 years
• BMI 18.5- 24.9 kg/m2 as per WHO Classification (1998)

Exclusion criteria

• Hyperlipidemia (TC>6.2 mmol/L, TAG >2.0 mmol/L)
• History of chronic disease- type 2 DM, heart disease, cancer
• Habitual smokers (>2 sticks a day)
• Hypertensives: >140/90 mmHg
• On medication/nutraceuticals to reduce blood lipids, blood pressure
• Pregnant or lactating women
• Planned trip abroad/overseas during period of study

Trial design

42 participants in 3 patient groups

Palm olein IV 64

Experimental group

Description:

Palm olein IV 64, n= 15, 4 weeks intervention

Treatment:

Other: Diet: Palm olein IV64

Cocoa butter

Experimental group

Description:

Cocoa butter, n= 15, 4 weeks intervention

Treatment:

Other: Diet: Cocoa butter

Virgin olive oil

Experimental group

Description:

Virgin olive oil, n= 15, 4 weeks intervention

Treatment:

Other: Diet: Virgin olive oil