Multidimensional Examination of Patients with Colorectal and Anal Cancer (MECACP)

University of Pecs

Status: Enrolling

Conditions: Anal Cancer; Physical Inactivity; Quality of Life; Fecal Incontinence; Colorectal Cancer

Treatments: Other: No intervention - cross-sectional observational study

Study type: Observational

Funder types: Other

Identifiers

NCT06562140

9636-PTE-2023

Details and patient eligibility

About

The aim of our cross-sectional research is to assess changes in physical activity, functional capacity, and health status in individuals with colorectal and anal carcinoma using subjective measurement tools, with particular focus on those suffering from incontinence, through a cross-sectional study. Additionally, the research involves the Hungarian adaptation and validation of the quality of life questionnaire for colorectal cancer (EORTC QLQ-CR29), quality of life questionnaire for anal cancer (EORTC QLQ-AN27), and Fecal Incontinence Severity Index (FISI)" questionnaires.

Full description

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. The incidence of CRC is known to be high in developed countries and increases with socioeconomic development. Well-known risk factors include aging, alcohol consumption, smoking, and obesity. In addition to family history, lifestyle changes in diet, occupation, or physical activity may also emerge as risk factors for CRC. Previous research findings have shown a significant association between reduced physical activity and an increased risk of CRC. With improved patient survival rates, functional outcomes such as fecal incontinence, urinary, and sexual dysfunction are becoming increasingly important, as they are known to significantly impact quality of life (QoL). Reviewing the functional outcomes of rectal cancer surgeries, it is observed that even years after surgery, one-third of patients suffer from fecal incontinence. In contrast, studies on the functional outcomes following colon cancer surgeries are rare and often involve relatively small study populations. Previous studies have shown that physical activity in cancer survivors can have numerous beneficial health effects and is associated with a reduced risk of cancer recurrence and mortality in cases of colon and rectal cancer.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult (18-80 years) patients with a diagnosis of colorectal or anal carcinoma

Exclusion criteria

• Neuromuscular diseases
• severe congenital musculoskeletal and other disorders,
• severe psychiatric illness, lack of cooperation,
• undergone other surgical procedures within the past year.

Trial design

300 participants in 2 patient groups

Colorectal cancer patients

Description:

Patients aged 18 to 80 years with a diagnosis of colorectal carcinoma

Treatment:

Other: No intervention - cross-sectional observational study

Anal cancer patients

Description:

Patients aged 18 to 80 years with a diagnosis of anal carcinoma

Treatment:

Other: No intervention - cross-sectional observational study