Multidisciplinary Approach to Reduce Cardiovascular Health Disparities (M-BRACE)

LifeBridge Health

Status: Enrolling

Conditions: Ischemic Stroke; Multi Vessel Coronary Artery Disease; Acute Coronary Syndrome

Treatments: Behavioral: Life and Medication Recommendations

Study type: Observational

Funder types: Other

Identifiers

NCT06168968

1941089

Details and patient eligibility

About

The goal of this observational study is to investigate the potential differences in thrombogenicity between black and white patients admitted with atherothrombotic events including acute coronary syndrome, multi-vessel coronary disease, and ischemic stroke.

Participants will engage in laboratory testing and health outcome assessments.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients ≥18 years of age admitted with ACS, AIS, or multi-vessel CAD
• Competent mental condition to provide informed consent and able to participate in follow-ups

Exclusion criteria

• Pregnant women
• Currently enrolled in an investigational drug or device trial
• Undergoing treatment for neoplastic, autoimmune, or connective tissue disease
• COVID-19 infection within 30 days of enrollment
• Known history of hepatitis or HIV
• Deemed unfit to participate according to the investigator
• Known history of drug abuse
• Known platelet count of <100,000/mm3
• Hematocrit < 25%

Trial design

400 participants in 2 patient groups

Patient

Description:

(Secondary Prevention) Includes black (n=150) and white (n=150) patients greater than or equal to 18 years of age hospitalized for acute coronary syndrome (ACS), multi-vessel disease, or ischemic stroke undergoing intervention

Treatment:

Behavioral: Life and Medication Recommendations

Family Member

Description:

(Primary Prevention) Includes black subjects (n=75) who are first or second-degree relatives of patients in Cohort 1 and have no history of prior hospitalization for cardiovascular or cerebrovascular disease

Treatment:

Behavioral: Life and Medication Recommendations