Multidisciplinary Combined Exercise and Nutrition Intervention for Sarcopenia (2) (MENTORS)

Seoul National University

Status

Completed

Conditions

Sarcopenia

Treatments

Combination Product: Combined exercise and nutrition intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT07028294

B-2010/645-005 (2)

RS-2020-KH095863 (Other Grant/Funding Number)

Details and patient eligibility

About

This is an empirical study, which aims to examine the effect of a 12-week combined exercise-nutrition intervention in older adults with sarcopenia and to provide data for clinical and policy decision-making of sarcopenia. The study conducts the combined exercise-nutrition intervention that was previously carried out as a randomized controlled trial. Hand grip strength, gait speed, knee extensor muscle power, physical performance, muscle mass using DEXA, quality of life, activities of daily living, sarcopenia screening questionnaire, nutritional assessment will be evaluated on baseline, 12-weeks and 24-weeks after intervention.

Full description

The definition of sarcopenia is age-related loss of skeletal muscle and physical functions. Sarcopenia is emerging health problem and increases medical expenditure as the population ages. Sarcopenia is closely related to chronic diseases and geriatric diseases. In particular, patients with metabolic syndrome showed a high prevalence of muscle loss and muscle weakness. It has been reported exercise in sarcopenia patients not only improved insulin sensitivity and physical performance but also helped the treatment of the diseases. Also, it has recently demonstrated that combined exercise-nutrition intervention improved muscle function in elderly patients. However, the standard protocol for the combined exercise-nutrition intervention has not been established yet. Therefore, this study aims to see the effects of a 12-week combined exercise-nutrition intervention in sarcopenia patients.

Enrollment

80 patients

Sex

All

Ages

65 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients older than 65 years and under 90 years
patients who meet the criteria for the Asian Working Group for Sarcopenia (AWGS) 2019
patients who had metabolic syndrome

Exclusion criteria

patients with less than estimated glomerular filtration rate (eGFR) 30
patients with musculoskeletal or chronic lung disease incapable of exercise
patients with untreated or uncontrolled cardiovascular disease which may affect muscle mass or performing exercise
patients less than 5 years after treatment of malignant tumor
patients with liver cirrhosis, diabetes and other chronic disease
patients who cannot perform combined exercise nutrition intervention for other reasons