Multidisciplinary Management of HCC in Elderly Patients

Azienda Policlinico Umberto I

Status: Completed

Conditions: Quality of Life; HCC

Treatments: Procedure: Thermic ablation; Procedure: liver resection; Procedure: Transcatheter arterial chemoembolization

Study type: Observational

Funder types: Other

Identifiers

NCT03875417

HEP001

Details and patient eligibility

About

Aim of this study is to evaluate whether treating HCC recurrences in resected elderly patients is advantageous or not.

Full description

Introduction- Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It usually develops in cirrhotic liver with high recurrence rates. More than 2/3 of patients are elderly, often excluded from surgery and follow-up protocols. Aim of this study is to evaluate whether treating HCC recurrences in resected elderly patients is advantageous or not.

Materials and methods- 126 patients, aged between 65 and 90 years, submitted to liver resection for HCC were enrolled. They were divided into three classes. Class 1 included patients submitted to major resections, Class 2 to minor resections and Class 3 to minor resections associated with thermoablation. All of them were clinically and radiologically followed up. Patients who developed recurrences (Group A) were referred to further treatments (surgery, interventional radiology or pharmacological therapy). Mortality, disease-free survival (DFS), overall survival (OS) and quality of life (QoL) were evaluated and compared with non-recurrent patients (Group B).

Used interventional radiology means were Radiofrequency ablation (RF), microwaves ablation (MWA) or transcatheter arterial chemoembolization (TACE).

Enrollment: 126 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HCC patient
• eligible for surgery

Exclusion criteria

• non eligible for surgery at first HCC diagnosis

Trial design

126 participants in 2 patient groups

Group A

Description:

Patients who developed HCC recurrences after surgery and treated with re-resection, or microinvasive non-surgical means.

Treatment:

Procedure: liver resection

Procedure: Transcatheter arterial chemoembolization

Procedure: Thermic ablation

Group B

Description:

Patients who did not develop recurrences after surgery.

Treatment:

Procedure: liver resection