Multidisciplinary Team IntervenTion in CArdio-ONcology (TITAN Study)

University of Alberta

Status and phase: Active, not recruiting; Phase 2

Conditions: Breast Cancer

Treatments: Behavioral: Multidisciplinary team intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01621659

TITAN 102

Details and patient eligibility

About

People with breast cancer often experience many short and long-term side effects as a result of both the cancer and the necessary treatments.

Receiving extra assessments and care from teams of multiple health professionals has been shown to be helpful for people with other health problems, such as heart disease. These 'multidisciplinary' teams may include nurses, doctors, pharmacists, dietitians, exercise therapists, counselors, and other specialists. Currently, the investigators do not know if receiving extra assessments from a multidisciplinary team is helpful for people receiving cancer treatment.

In this study, the investigators hope to learn the effect of extra assessments and early interventions from teams of health care professionals in people diagnosed with cancer, during and after the treatment period.

After initial assessments, participants will be randomized to multidisciplinary team intervention or usual care.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed malignancy (breast or lymphoma);
• scheduled to receive anthracycline and/or trastuzumab-based chemotherapy;
• age ≥ 18 years;
• willing to attend follow-up visits.

Exclusion criteria

• physical disability preventing exercise testing or DEXA scan;
• psychiatric disease or disorder precluding informed consent;
• participation in other cardiotoxicity or exercise intervention study;
• contraindication to anti-cancer therapy, including known heart failure, cardiomyopathy, or baseline LVEF < 50%;
• previous anthracycline or trastuzumab-based therapy;
• previous radiotherapy to thorax.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

multidisciplinary team intervention

Experimental group

Description:

Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist

Treatment:

Behavioral: Multidisciplinary team intervention

Observational arm

No Intervention group

Description:

Participants randomized to observational arm will receive usual care.