Multidrug Resistance After Trabeculectomy With Mitomycin C

University of Cologne

Status: Completed

Conditions: Trabeculectomy; Glaucoma

Study type: Observational

Funder types: Other

Identifiers

NCT00449631

Multidrug Resistance

Details and patient eligibility

About

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Full description

Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Sex: All

Ages: 8 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with planned trabeculectomy for elevated eye pressure
• one third of patients without previous trabeculectomy
• two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion criteria

• patients not requiring surgery
• patients with planned surgery for elevated eye pressure other than trabeculectomy