Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn

University of North Carolina (UNC)

Status: Completed

Conditions: Multi-drug Resistant Gram-negative Bacilli Colonization

Treatments: Other: MDR-GNB

Study type: Observational

Funder types: Other

Identifiers

NCT02653157

15-1505

US NIH Grant KL2TR001109 (Other Grant/Funding Number)

Details and patient eligibility

About

This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically ill burn patients.

Full description

This is a prospective observational study. Patients will be followed during a single admission for development of colonization or infection with MDR-GNB. Patient clinical characteristics, including infections, surgeries, and antibiotic exposure, will be collected in real-time.

Weekly surveillance wound and peri-rectal swabs and, if intubated, biweekly deep endotracheal or tracheostomy aspirates will be collected, de-identified, and stored from all patients and examined for the presence of MDR-GNB. All GNB isolates from blood, urine, respiratory, and wound cultures will be collected, coded, and stored.

Enrollment: 48 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Severe burn injury, including partial or full thickness burn 20% or more total body surface area; or
2. inhalation injury; or
3. 18 years of age or older;

Exclusion criteria

1. Intensive care unit stay of less than 5 days;
2. ICU admission more than 48 hours after burn trauma.

Trial design

48 participants in 1 patient group

Burn patients with VAT or VAP with MDR-GNB

Description:

Adult patients with burn and/or inhalation injury requiring intubation

Treatment:

Other: MDR-GNB