Multifamily Psychoeducation and Cognitive Remediation for Recent-Onset Psychosis

University of Arizona

Status: Completed

Conditions: Schizophrenia; Bipolar Disorder With Psychotic Features; Schizoaffective Disorder; Major Depression With Psychotic Features; Recent-Onset Psychosis; Psychotic Disorder Not Otherwise Specified (NOS)

Treatments: Behavioral: Multifamily Group Psychoeducation (MFG); Behavioral: Cognitive Remediation (CR)

Study type: Interventional

Funder types: Other

Identifiers

NCT01196286

2010-BN-07

Details and patient eligibility

About

The goal of this study is to determine whether pairing multifamily group psychoeducation with cognitive remediation may facilitate improved outcomes among individuals with recent-onset psychosis.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (Individual with Recent-Onset Psychosis):

• Diagnosis of a non-substance induced psychotic disorder per DSM-IV-TR criteria determined using the Structured Clinical Interview for the DSM-IV.
• Age between 18-35
• Willing to participate in interventions at University of Arizona Medical Center, South Campus
• Willing to complete research assessments
• Duration of psychotic symptoms of less than 5 years determined using the Symptom Onset in Schizophrenia inventory
• Able to provide informed consent
• Fluent in English
• Must have a family caregiver who is willing to participate in the study
• Willing to allow videotaping of multifamily group therapy sessions.
• No evidence of mental retardation as defined as never having qualified to receive services from the Arizona Department of Economic Security, Division of Developmental Disabilities.

Exclusion Criteria (Individual with Recent-Onset Psychosis):

• Failure to meet inclusion criteria

Inclusion Criteria (Caregiving Relative of Individual with Recent-Onset Psychosis):

• Must be someone that the individual with recent-onset psychosis identifies as providing support and care to the individual with recent-onset psychosis. Does not need to be a biological relative.
• Must spend considerable time with the individual with recent-onset psychosis as defined at 10 hours or more of direct contact per week.
• Willing to participate in participate in family intervention at University of Arizona Medical Center, South Campus for 2 years
• Willing to complete research assessments
• Able to provide informed consent
• Fluent in English
• Willing to allow videotaping of multifamily group sessions.

Exclusion Criteria (Caregiving Relative of Individual with Recent-Onset Psychosis):

• Failure to meet inclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

MFG and CR

Experimental group

Description:

Subjects provided with both multifamily psychoeducation (MFG) and cognitive remediation (CR)

Treatment:

Behavioral: Multifamily Group Psychoeducation (MFG)

Behavioral: Cognitive Remediation (CR)

MFG

Active Comparator group

Description:

Subjects provided with only multifamily group psychoeducation (MFG)

Treatment:

Behavioral: Multifamily Group Psychoeducation (MFG)