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Multifocal HD-tDCS and Motor Function

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University of Michigan

Status

Not yet enrolling

Conditions

Healthy

Treatments

Device: Standard HD-tDCS intervention
Device: Functional Magnetic Resonance Imaging (fMRI)
Device: Multifocal network targeted HD-tDCS intervention

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT06561165
HUM00250171
5P2CHD086844-10 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.

The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.

Full description

This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.

Enrollment

40 estimated patients

Sex

All

Ages

65 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Participants should be in good health with normal or corrected-to-normal visual acuity
  • Right handed
  • No history of neurological disorder
  • English speaker
  • Able to provide written consent prior to admission

Exclusion criteria

  • Left-handed
  • Participants are pregnant, suspect pregnancy or are attempting to become pregnant
  • Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump
  • Have cochlear hearing implants
  • Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol)
  • Have non removable body piercings or have foreign objects in body
  • Have metal anywhere in the head that could increase risk of serious injury (not including braces, dental fillings, etc.) (see protocol)
  • Have a personal or family history of seizure/epilepsy
  • Taking prescription drugs that lower the threshold for seizures
  • Recent history of excessive alcohol consumption
  • History of alcohol addiction/dependence
  • Recent history of recreational drug use
  • History of drug addiction/dependence
  • Recent history of recreational drug use
  • History of drug addiction/dependence
  • Diagnosed with a stroke, brain hemorrhage, brain tumor, encephalitis.
  • Diagnosed with multiple sclerosis
  • Diagnosed with Parkinson's disease or Alzheimer's disease
  • Diagnosed with depression in the past 6 months
  • Diagnosed with attention deficit disorder, schizophrenia, manic depressive (bipolar) disorder
  • Diagnosed with normal pressure hydrocephalus or increased intra-cranial pressure
  • Diabetes requiring insulin treatment
  • Any serious heart disorder or liver disease

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

40 participants in 2 patient groups

HD-tDCS with standard intervention
Experimental group
Description:
Participants will have three daily sessions.
Treatment:
Device: Functional Magnetic Resonance Imaging (fMRI)
Device: Standard HD-tDCS intervention
Personalized dose-controlled multifocal network-targeted HD-tDCS.
Experimental group
Description:
Participants will have three daily sessions.
Treatment:
Device: Multifocal network targeted HD-tDCS intervention
Device: Functional Magnetic Resonance Imaging (fMRI)

Trial contacts and locations

1

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Central trial contact

Michael Vesia, PhD

Data sourced from clinicaltrials.gov

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