Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption

Mass General Brigham

Status and phase: Withdrawn; Early Phase 1

Conditions: Pain

Treatments: Drug: Multimodal analgesia

Study type: Interventional

Funder types: Other

Identifiers

NCT03817034

2018P002053

Details and patient eligibility

About

The investigators are performing this research study to investigate the efficacy of local infiltration of the surgical wound combining dexmedetomidine, ropivacaine, and ketorolac (treatment group) versus the current standard of care (historical control group), for post-operative pain management.

Full description

During this research study, patients recommended for a rectus sheath block during surgery will receive a novel combination of non-opioid drugs. Data from the treatment group will be compared to surgical outcomes of a historically matched control group to investigate the ability of this drug combination to reduce post-operative pain and post-operative opioid consumption.

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age greater than 18 years
• American Society of Anesthesiologist Physical Status Classification 1-3
• Undergoing surgery requiring a rectus sheath block

Exclusion criteria

• American Society of Anesthesiologist Physical Status Classification of 4 or beyond
• history of opiate of illicit substance abuse, chronic pain, or neurological dysfunction

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Multimodal Analgesia

Experimental group

Treatment:

Drug: Multimodal analgesia