Multimodal and Unimodal Analgesia in Cholecystectomy

October 6 University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Compare Unimodal and Multimodal Analgesics

Treatments: Drug: Acetaminophen 1 G Oral Tablet; Drug: Celecoxib 400Mg Oral Capsule; Drug: Pregabalin 150mg

Study type: Interventional

Funder types: Other

Identifiers

NCT05547659

FWA00015574

Details and patient eligibility

About

Many surgical procedures are accompanied by postoperative pain with severity moderate, severe or extreme and insufficient postoperative pain control may cause risk of post-surgical complications and risk of chronic post-surgical pain The targets of preoperative pain management are to relieve patient suffering, reduce length of hospital stay and achieve early mobilization after surgery, decreasing opioid consumption and its side effects that are constipation, nausea, vomiting, dizziness, respiratory depression which is the most feared complication being life-threatening and some less common side effects as sedation

Enrollment: 95 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing laparoscopic cholecystectomy
• Patients older than 18 years old

Exclusion criteria

• Renal or hepatic or cardiac impairment patients
• Patients with chronic pain history
• Allergic patients after taking aspirin or other NSAIDs
• patients with active gastrointestinal bleeding, ulcer and inflammatory bowel diseases or cerebrovascular bleeding

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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95 participants in 3 patient groups

multimodal

Active Comparator group

Description:

pregabalin/ acetaminophen/ celecoxib

Treatment:

Drug: Pregabalin 150mg

Drug: Acetaminophen 1 G Oral Tablet

Drug: Celecoxib 400Mg Oral Capsule

unimodal

Active Comparator group

Description:

Pregabalin

Treatment:

Drug: Pregabalin 150mg

control

No Intervention group