Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients

Pontificia Universidad Catolica de Chile

Status: Completed

Conditions: Cardiotoxicity; Breast Cancer; Esophageal Cancer; Radiotherapy; Complications; Lung Cancer; Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04896242

11190071

Details and patient eligibility

About

The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity in cancer patients receiving low or high doses of radiotherapy.

Enrollment: 47 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥18 year-old patients
• With histologically confirmed thoracic cancer (breast, esophagus or lung)
• Recommendation of thoracic radiotherapy (RT) with curative intent
• With or without chemotherapy
• All patients must be able to read and understand Spanish
• All patients must sign informed consent form.

Exclusion criteria

• Patients with no medical records,
• Pregnant
• Previously diagnosed with severe left ventricular dysfunction or a cardiac insufficiency
• Patients with metastatic disease and indication of palliative RT
• Patients with significant comorbidities associated to a <5 year life expectancy.
• Patients previously treated with thoracic RT