Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy

The Second Hospital of Anhui Medical University

Status: Enrolling

Conditions: Major Depressive Disorder; Electroconvulsive Therapy; Magnetic Seizure Therapy

Treatments: Other: Cognitive and Behavioral Assessment; Device: Magnetic Seizure Therapy; Device: Electroconvulsive Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT07473648

AHMU-MST/ECT-MDD

Details and patient eligibility

About

To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).

Enrollment: 200 estimated patients

Sex: All

Ages: 12 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patients Inclusion Criteria:

Aged 12-80 years; Diagnosis confirmed by two psychiatrists per DSM-5; Stable medication regimen pre-enrollment; Indicated for neuromodulation OR with visual field defects.

Patients Exclusion Criteria:

Major systemic diseases; Prior neuromodulation within 3 months; Pregnancy or potential pregnancy; Metal implants or claustrophobia.

Healthy Control Inclusion Criteria:

Aged 12-80 years; No history of neuropsychiatric disorders; No significant systemic diseases; Normal or corrected vision.

Healthy Control Exclusion Criteria:

Metal implants or claustrophobia; Ocular diseases or surgery history.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 3 patient groups

Electroconvulsive Therapy (ECT) Group

Experimental group

Description:

Participants with Major Depressive Disorder(MDD) receive active Electroconvulsive Therapy (ECT) according to the study protocol, in addition to their ongoing standardized pharmacotherapy. This group assesses the efficacy and cognitive effects of ECT.

Treatment:

Device: Electroconvulsive Therapy

Other: Cognitive and Behavioral Assessment

Magnetic Seizure Therapy (MST) Group

Experimental group

Description:

Participants with Major Depressive Disorder (MDD) receive active Magnetic Seizure Therapy (MST) according to the study protocol, in addition to their ongoing standardized pharmacotherapy. This group assesses the efficacy and cognitive effects of MST, allowing for comparison with ECT.

Treatment:

Device: Magnetic Seizure Therapy

Other: Cognitive and Behavioral Assessment

Healthy Control Group

Other group

Description:

Healthy volunteers with no history of major neuropsychiatric disorders. They do not receive any neuromodulation intervention (ECT or MST) or study-related pharmacotherapy. They undergo the same cognitive and behavioral assessments at matched time points to provide normative baseline data for comparison.

Treatment:

Other: Cognitive and Behavioral Assessment