Multimodal Evaluation of Cartilage Lesions of Patellofemoral Joint (MULTICART)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Knee Osteoarthritis

Study type: Observational

Funder types: Other; NETWORK

Identifiers

NCT03210584

38 RC16.213

Details and patient eligibility

About

Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.

Full description

Knee osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration. This observationnal, pilot, prospective, non randomized, uncontrolled, monocentric study aim to compare three of the most innovative imaging systems, namely the 9,4 Tesla MRI, the FFOCT (Full-Field Optical Coherence Tomography) and the ultrasound-based navigation system in order to image healthly to severely degraded human cartilage samples. All methods will be cross-correlated and compared with histological data considered as the gold standard.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Over 18 years of age
• Knee prosthetic surgery indication with cartilage excision.

Exclusion criteria

• Subjects who refuse to sign a non-objection form

Trial design

10 participants in 1 patient group

Imaging measurements

Description:

All subject of the study have a knee osteoarthritis (OA) and are going to have a knee prosthetic surgery with cartilage excision. Multimodal evaluation is conducted on ex vivo human cartilage samples (2 samples per patient are selected : healthy and severely degraded).