Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque

Lausanne University Hospital (CHUV)

Status and phase

Enrolling

Phase 2

Phase 1

Conditions

Atheromatous Plaques

Inflammation

Carotid Artery Diseases

Treatments

Drug: 68Ga-NODAGA-RGD PET/CT

Study type

Interventional

Funder types

Other

Identifiers

NCT01608516

80/10

Details and patient eligibility

About

The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology.

Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.

Full description

Patients with indication for endarterectomy will be presented the present protocol. If inclusion criteria are fulfilled, patients will have a 18F-FDG PET/CT + carotid US performed 6 to 2 days before endarterectomy and 68Ga-NODAGA-RGD PET/CT + MRI performed the day before endarterectomy. Histopathological sample will be analyzed to measure plaque inflammation.

All imaging results and histopathology results will be pooled and compared.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age <= 85 years
Karnofsky >= 80%
patient with indication ofr carotid endarterectomy
signed consent form

Exclusion criteria

indication for surgery other than endarterectomy <14 days
contraindication to surgery
contraindication to MRI
contraindication to gadolinium injection (stage 4/5 kidney insufficiency, GFR<30ml/min/1.73m2)
pregnancy, breastfeeding
lack of discernment