Multimodal Investigation of Intracranial Clot Environment (MISO)

University Hospital Center (CHU)

Status: Enrolling

Conditions: Brain Ischemia; Acute Ichemic Stroke

Treatments: Other: Analysis of the clot

Study type: Observational

Funder types: Other

Identifiers

NCT04421326

RECHMPL18_0236

Details and patient eligibility

About

Analysis of peri clot blood collected at the acute phase of stroke in order to understand physiopathological mechanisms involved in the cerebrovascular damage

Full description

It has been shown that immune cells accumulate around the clot at the acute phase of stroke. Leukocytes and their specific chemokines and cytokines regulation may impact cerebrovascular integrity.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Over 18 years of age,
2. Non-dependent for activities of daily living prior to the onset of the MI (Modified Rankin Score >2)
3. Having an occlusion of a large arterial trunk proven by imaging (angio-MRI or angio-scanner).

Exclusion criteria

1. Patients initially admitted but for whom endovascular treatment will not finally be performed (re-infusion, catheterization failure...) will be excluded from the study.
2. Major patients under guardianship or curatorship or patients deprived of liberty

Trial design

200 participants in 1 patient group

Patients with acute ischemic stroke

Description:

Patients undergoing Mechanical Thrombectomy for large vessel occclusion with acute ischemic stroke

Treatment:

Other: Analysis of the clot