Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks (THC-MEG)

Yale University

Status and phase: Not yet enrolling; Phase 2

Conditions: THC

Treatments: Other: Placebo; Drug: THC

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05641766

2000033383

1R03DA054453-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.

Full description

The goal of this study is to use multimodal MEG/EEG to gain novel insight into the acute effects of THC on neural noise and its interaction with the fast information processing dynamics of the brain's cognition-related functional neural networks.

Enrollment: 50 estimated patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Cannabis use at least once in the past 12 months
• No cannabis use during the course of the study confirmed with negative urine toxicology at screening and on each test day
• Good physical and mental health

Exclusion criteria

• Cannabis naïve individuals
• Lifetime or current medical, psychiatric or psychosocial disorders or history that is deemed unsuitable for participation in the study per PI discretion.
• Positive pregnancy test, lactation, or refusal to practice birth control for the duration of the study and for two weeks following completion
• Major current or recent stressors
• Positive urine drug test
• Contraindication for Magnetic Resonance Imaging
• Treatment with psychotropic medication as per discretion of the PI
• IQ less than 80
• Weight exceeding 166kg
• Diagnosis of major psychotic or manic disorder in first-degree relatives.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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50 participants in 2 patient groups

THC

Experimental group

Description:

Participants will receive THC into a rapidly flowing IV infusion.

Treatment:

Drug: THC

Placebo

Other group

Description:

Participants will receive an equivalent amount (about 1-2 ml) of placebo (sterile 190 proof USP ethanol). The placebo does not produce any measurable blood alcohol levels or subjective/behavioral effects.

Treatment:

Other: Placebo