Multimodal Pain Therapy After Hernia Repair

Khashayar Vaziri

Status and phase: Withdrawn; Phase 2

Conditions: Hernia, Abdominal; Pain

Treatments: Drug: acetominophen, ibuprofen, oxycodone; Drug: Oxycodone

Study type: Interventional

Funder types: Other

Identifiers

NCT03792295

MultimodalHernia

Details and patient eligibility

About

Investigating the effect of multimodal pain treatment after hernia repair

Full description

This is a randomized, non-blinded study comparing the effects of multimodal pain management (ibuprofen, tylenol, and narcotics/oxycodone as needed) for relief of post-operative pain in patients who undergo hernia repair. Patients who present for elective hernia surgery will be randomized in a 1:1 fashion by pre-operative pain score into a multimodal pain treatment group or conventional opiod treatment group for post-operative pain management. They will be followed up after their surgery to evaluate their pain scores and narcotic use.

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult patients >18 years of age to 90 years of age who are eligible for a hernia repair (ventral or inguinal) by a surgeon in the Medical Faculty Associates Department of General Surgery at the George Washington University Hospital.

Exclusion criteria

• Patients with allergies to sulfa or any of the medications being evaluated in this study (ibuprofen, tylenol, oxycodone)
• patients with a history of gastric ulcer or gastrointestinal bleeding
• patients with kidney disease
• patients with cardiovascular disease
• patients with a co-morbid condition that would prohibit them from taking narcotics
• patients with known or suspected narcotic abuse
• patients who do not wish to participate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Multimodal Therapy

Experimental group

Description:

Patients will receive scheduled ibuprofen 400mg po q 4 hours and acetominophen 1gram po q 8 hours during the post operative phase and oxycodone 5mg po q 4 to 6 hours as needed for pain control.

Treatment:

Drug: acetominophen, ibuprofen, oxycodone

Classic/standard opiod Therapy

Active Comparator group

Description:

Patients will receive oxycodone 5mg po q 4 to 6 hours as needed during their post operative phase for pain control.

Treatment:

Drug: Oxycodone