Multimodal PET Imaging in the Diagnosis and Treatment of Pelvic Tumors

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Endometrial Cancer

Treatments: Diagnostic Test: three kinds of examinations

Study type: Interventional

Funder types: Other

Identifiers

NCT06774209

PUMCH-NM-Pelvic Tumors-FAPI

Details and patient eligibility

About

This study is a prospective exploratory study to explore the application value of gallium 68 labeled-fibroblast activation protein inhibitor-04 Positron Emission Tomography（68Ga-FAPI-04 PET）imaging in patients with endometrial cancer and compare it with the imaging agent with better imaging effects to study its advantages. After patient enrollment, 68Ga-FAPI-04 Positron Emission Tomography/Computed Tomography（PET/CT） and Positron Emission Tomography/Magnetic Resonance Imaging（PET/MRI） examinations are performed, with the imaging agent administered intravenously at a dose of 0.02 to 0.04 mCi/Kg×patient weight (Kg), and a whole-body scan is performed 30-60 minutes later, with images processed as usual. Within 1 week before and after the examination, Fluorine18 labeled-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography（18F-FDG PET/CT） is completed, along with medical history collection and necessary laboratory tests. Subsequently, patients undergo surgical resection of the lesion and suspicious metastatic lymph nodes shown by FAPI PET/CT to obtain the corresponding pathological results. Finally, the diagnostic value of all patients in 68Ga-FAPI-04 PET/CT and PET/MR is analyzed and compared with 18F-FDG PET/CT to study the differences in diagnostic efficacy between the two.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-70 years old
• Obtaining written informed consent
• Being able to accept follow-up
• Feasible surgery or biopsy to obtain the final result

Exclusion criteria

• Pregnant and lactating female patients
• Patients who are difficult to receive further diagnosis and treatment due to their severe condition
• Any patients with contraindications to magnetic resonance imaging

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

imaging examinations

Experimental group

Description:

The study recruited patients suffering from endometrial cancer, and three types of examinations will be performed on them.

Treatment:

Diagnostic Test: three kinds of examinations