Multimodal Study of the Human Brain Epilepsy Tissue (TIPI²)

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Focal Drug-resistant Epilepsy

Treatments: Other: Blood and tissue collection

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06022055

APHP230479

Details and patient eligibility

About

The TIPI2 study is a blood and tissue collection protocol to create an annotated biorepository to support research in drug-resistant epilepsy.

The aim of the study will be to identify new pathophysiological pathways. For this purpose, the investigators will investigate with a multimodal approach blood and brain samples from patients undergoing a surgery for focal drug-resistant epilepsy. The adult patients will be enrolled either during the pre-surgical evaluation or right before the surgery.

Full description

This study aims to investigate blood and brain samples from patients with drug-resistant epilepsy in order to identify new pathophysiological biomarkers.

The investigators will first conduct multimodal research, including:

• electrophysiological analyses
• immunohistochemistry and genetic studies
• biochemistry analyses

Samples will be stored at -80°C for future research.

Patients will undergo a follow-up evaluation within the 36 months following the surgery. New clinical data and biological samples will be collected then.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 yo or above
• patients with a focal drug-resistant epilepsy
• patients hospitalized for a pre-surgical evaluation or for an epilepsy surgery
• consent obtained from the patient, or legally authorized representative
• affiliated to a social security system

Exclusion criteria

• None

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

epileptic patients

Experimental group

Description:

All patients will be enrolled in the same arm. Patients can be enrolled during the pre-surgical evaluation (group 1) or in the days preceding the surgery (group 2).

Treatment:

Other: Blood and tissue collection