Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

Mayo Clinic

Status

Enrolling

Conditions

Left Ventricular Systolic Dysfunction

Treatments

Diagnostic Test: Cardiac MRI

Study type

Observational

Funder types

Other

Identifiers

NCT06770062

24-009436

Details and patient eligibility

About

The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age >= 18
Male or Female
A diagnosis of severe chronic primary mitral regurgitation
Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
Patients must have the ability to consent or have an appropriate representative available to do so.

Exclusion criteria

Prior valve intervention,
Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
Concomitant >= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
History of prior myocardial infarction
History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
Implantable devices that would be a contraindication to MRI
Severe allergy to gadolinium MRI contrast