Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury (MOSS-FAST)

Shanghai Jiao Tong University

Status: Enrolling

Conditions: Brain Injuries, Traumatic

Treatments: Other: Type of disease

Study type: Observational

Funder types: Other

Identifiers

NCT05778123

LY2023-018-B

Details and patient eligibility

About

The goal of this experimental observation study is to figure out differently expressed biomarkers in body fluid in traumatic brain injury patients. The main questions it aims to answer is:

• Which RNA, protein and metabolites are differently expressed in lesion tissues?
• What molecular mechanism is participated in TBI? Participants will be treated by emergency operation, and their body fluid samples will be collected in emergency room and during the operation.

Enrollment: 10 estimated patients

Sex: All

Ages: 16 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age >18 and <65
2. Within 12 hours after brain injury
3. Control group is hydrocephalus
4. GCS ≥3 and ≤8
5. Closed brain injury with frontotemporal contusion
6. Need emergency intracranial hematoma evacuating or cerebrospinal fluid shunting operation
7. Patient's agents are informed and consent the research

Exclusion criteria

1. With TBI, stroke, ICH or intracranial tumor history
2. Death within 24 hours
3. Immunosuppression state
4. Severe organ dysfunction
5. Complicated infective disease
6. Pregnant

Trial design

10 participants in 2 patient groups

TBI

Description:

Patients with traumatic brain injury.

Treatment:

Other: Type of disease

Control

Description:

Patients with hydrocephalus.

Treatment:

Other: Type of disease