Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases

Central Hospital, Nancy, France

Status: Not yet enrolling

Conditions: Pediatric Inflammatory Multisystem Syndrome; Myocarditis; Kawasaki Disease

Treatments: Other: study of biological samples and echocardiographic data and link with need of hemodynamic support

Study type: Observational

Funder types: Other

Identifiers

NCT05911386

2023PI058

Details and patient eligibility

About

Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).

These 3 inflammatory cardiac diseases have clinical, biological, and echographic similarities and differences. Nevertheless their modalities of monitoring, management and evolution are different. The investigators wish to retrospectively analyze biological and echocardiographic data of Kawasaki disease, myocarditis, PIMS patients managed at Nancy Children Hospital from January 1, 2017 to June 31, 2023.

The primary objective of this study is to identify, for these 3 pathologies, the prognostic factors of initiation of inotropic support.

The secondary objective is to identify the prognostic factors of degradation of ventricular function.

Enrollment: 100 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnostic of PIMS, myocarditis or kawasaki disease patients
• age < 18 years

Exclusion criteria

• uncertain diagnosis
• other complex heart disease
• management out of Nancy University children hospital center

Trial design

100 participants in 3 patient groups

MYOCARDITIS

Description:

No intervention Study of available clinical, biological, and echocardiographic data

Treatment:

Other: study of biological samples and echocardiographic data and link with need of hemodynamic support

KAWASAKI

Description:

No intervention Study of available clinical, biological, and echocardiographic data

Treatment:

Other: study of biological samples and echocardiographic data and link with need of hemodynamic support

PIMS

Description:

No intervention Study of available clinical, biological, and echocardiographic data

Treatment:

Other: study of biological samples and echocardiographic data and link with need of hemodynamic support