Multiparametric Imaging in Multiple Myeloma

Yingbing Wang

Status and phase: Completed; Phase 1

Conditions: Multiple Myeloma

Treatments: Drug: C11 Methionine positron emission tomography

Study type: Interventional

Funder types: Other

Identifiers

NCT02646085

2015P001579

Details and patient eligibility

About

Patients with Multiple Myeloma will undergo single timepoint Positron Emission Tomography imaging with intravenously injected C11 Methionine to detect viable lesions.

Enrollment: 10 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Multiple Myeloma with symptomatic bone or soft tissue disease
• Eastern Cooperative Oncology Group status 0 to 2
• Life expectance >= 12 weeks
• Ability to understand and willingness to sign informed consent
• Tissue sampling with genotype data planned within 3 months of C11 positron emission tomography (PET) imaging

Exclusion criteria

• Pregnant or breast feeding
• Claustrophobic reactions and unable to lie still on a bed inside the PET scanner for 60 minutes
• Research related radiation exposure exceeding 50 millisieverts

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

10 participants in 1 patient group

Intervention

Experimental group

Description:

C11 Methionine positron emission tomography (PET/CT) studies will be performed as hybrid PET/CT examinations for attenuation correction and lesion localization. A bolus of 10 millicuries of C11 Methionine will be injected intravenously. Approximately 60 minutes following tracer injection, the patient will be positioned on a Siemens Biograph PET/CT scanner. A low milliampere CT of from the mid skull to mid thigh will be acquired first with while the patient is free breathing. PET will be acquired at 3 minutes per bed position using the 3D mode, approximately 6-7 bed positions. C11 Methionine PET/CT imaging will take less than 60 minutes.

Treatment:

Drug: C11 Methionine positron emission tomography