Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Grünenthal

Status and phase

Terminated

Phase 1

Conditions

Healthy

Treatments

Drug: Patch with centrally acting analgesic

Drug: Transtec(R) PRO (buprenorphine)

Study type

Interventional

Funder types

Industry

Identifiers

NCT00387777

2006-003177-27 (EudraCT Number)

HP5303/10 (Other Identifier)

631766

Details and patient eligibility

About

The purpose of this study is to determine whether Transtec(R) PRO 70 µg/h and a new buprenorphine patch formulation lead to same plasma levels of buprenorphine after multiple dose application.

Full description

Main: To demonstrate the bioequivalence of the new buprenorphine transdermal patch T2rev formulation containing 13 mg buprenorphine (Test) as compared to Transtec(R) PRO 70 µg/h patch transdermal patch containing 40 mg buprenorphine as reference after multiple patch application. Pharmacokinetic target parameters are AUCss,Tau and Css,max.

Further: To assess the safety, tolerability, skin tolerability and adhesiveness of the patch applications. To evaluate the following further Pharmacokinetic parameters: Css,min, Css,ave, PTF, Swing, tss,max, and t1/2,z

Sex

Male

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male Caucasian subjects, aged 18 - 55 years
BMI between 18 and 30 kg/m2 inclusive, with a lover limit of body weight of 50 kg
Subjects must be in good health as determined by medical history, physical examination, 12-lead electrocardiogram, vital signs, and clinical laboratory parameters
Subjects giving written informed consent to participate within this trial

Exclusion criteria

Resting pulse rate <= 45 or >= 100 beats/min
Resting blood pressure:systolic blood pressure <= 90 and >= 160 mmHg, diastolic blood pressure <= 40 and >= 100 mmHg
History or presence of orthostatic hypotension
Positive test of HIV type 1/2 antibodies, HBs antigen, HBc antibodies, HCV antibodies
Participation in another clinical trial in the last 30 days before starting this trial (i.e., first administration of IMP)
Positive drug of abuse screening
Diseases or condition known to interfere with the absorption, distribution, metabolism or excretion of drugs
Marked repolarisation abnormality (e.g., suspicious or definite congenital long QT syndrome with QT/QTc>500msec or prolonged QTc, i.e.>450msec) or co-medication that is known to influence cardiac repolarisation substantially
Bronchial asthma
Definite or suspected history of drug allergy or hypersensitivity
Subjects who have received any prescribed and non-prescribed systemic or topical medication like analgesics, NSAIDs (except standard dose of a NSAID once a week for the treatment of headache), hypnotics, sedatives, narcotics, neuroleptics or other medications that may lower the seizure threshold, MAO-inhibitors, serotonin-reuptake-inhibitors, tricyclic antidepressants, other centrally acting substances and substances which are known to interact with the drug metabolizing enzymes (e.g., inhibitors or inducers of CYP3A4 or CYP2D6) four weeks prior to the start of the trial (i.e, first administration of IMP). Each case has to be decided upon individually by the investigator after consultation with the sponsor
Evidence of alcohol or drug abuse
Not able to abstain from consumption of:
Caffeine containing beverages or food (tea, coffee, cola, chocolate, etc.)
Quinine containing beverages or food (bitter lemon, tonic water)
Grapefruit juice (sweet, sour)
Poppy seeds containing beverages or food
Blood loss (> 100 mL) due to e.g., blood donation within 3 months before starting this trial (i.e., first administration of IMP)
History of seizures or at risk (i.e. head trauma, epilepsy in family anamnesis, unclear loss of consciousness)
Known or suspected of not being able to comply with the trial protocol
Not able to communicate meaningfully with the investigator and staff
Smoking of > 10 cigarettes/day or equivalent.

Trial specific exclusion criteria:

Subjects not able to abstain from strenuous exercise during the whole course of the trial
Abnormality (e. g. scar, tattoo) or unhealthy skin at application site according to examination by the investigator
Existing chronic skin disease or history of skin disease at the application site within the last 4 weeks
Presence of one of the contraindications as detailed in the current Summary of Product Characteristics (SmPC).