Multiple Doses of BI 207127 NA, BI 201335 NA Followed by the Combination of BI 207127 NA and BI 201335 NA in Healthy Male Volunteers

Boehringer Ingelheim

Status and phase

Terminated

Phase 1

Conditions

Healthy

Treatments

Drug: Midazolam

Drug: Tolbutamide

Drug: BI 207127 NA

Drug: BI 201335 NA

Study type

Interventional

Funder types

Industry

Identifiers

NCT02182401

1241.18

Details and patient eligibility

About

Study to investigate the pharmacokinetic drug-drug interaction potential of BI 207127 NA and BI 201335 NA on each other at steady-state and to quantify the effect of BI 207127 NA, and BI 207127 NA combined with BI 201335 NA, on the activity of CYP 2C9 and CYP 3A4 using the probe substrates tolbutamide (CYP 2C9) and midazolam (CYP 3A4).

Enrollment

37 patients

Sex

Male

Ages

21 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy males (caucasian)
Age ranging ≥ 21 and ≤ 50 years
Body mass index (BMI) ≥ 19 and ≤ 29.9 kg/m2
Willing to complete all study-related activities
Volunteers give their written informed consent prior to admission to the study

Exclusion criteria

Any finding of the medical examination (including blood pressure, pulse rate and electrocardiogram) deviating from normal and of clinical relevance
Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders, clinically relevant electrolyte disturbances
Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders
History of photosensitivity or recurrent rash
History of orthostatic hypotension, fainting spells or blackouts
Chronic or clinically relevant acute infections
History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator
Intake of drugs with a long half-life (> 24:00 hours) within at least one month or less than ten half-lives of the respective drug before enrolment in the study or during the study
Use of any drugs which might influence the results of the trial up to 7 days prior to enrolment in the trial or during the trial
vulnerable subjects (that is persons kept in detention)
exclusion of contraindications or hypersensitivity to midazolam and / or tolbutamide
Participation in another trial with an investigational drug (within two months prior to administration or during the trial)
Smoker (> 10 cigarettes or > 3 cigars of > 3 pipes/day)
Inability to refrain from smoking on trial days
Alcohol abuse (> 60 g/day)
Drug abuse
Blood donation (> 100 mL within four weeks prior to administration or during the trial)
Any laboratory value outside the reference range if indicative of underlying disease or poor health
Excessive physical activities within the last week before the trial or during the trial
Hypersensitivity to treatment medication and/or related drugs of these classes
A marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTcF, or QTcB interval >450 ms)
Homozygous carriers of the UGT1A1 (uridine diphosphate glucuronosyltransferase 1A1) enzyme polymorphism *28 and *60