ClinicalTrials.Veeva

Menu

Multiplex Testing for Breast Cancer Susceptibility: A Pilot Study of Subject Preferences for Information and Responses After Testing

Memorial Sloan Kettering Cancer Center (MSK) logo

Memorial Sloan Kettering Cancer Center (MSK)

Status

Completed

Conditions

Breast Cancer

Treatments

Behavioral: Pre-test Assessment
Behavioral: Pre test Counseling
Other: Blood draw
Behavioral: Follow-up assessments (6 and 12 months)
Behavioral: Post-test counseling, and post-test assessment

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is to find out what kinds of information people would like to receive from a new kind of genetic testing, and how they respond to this new kind of testing.

Enrollment

197 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Male or Female age 18 or older
  • Personal history of breast cancer AND one of the following:
  • Invasive breast cancer or DCIS diagnosed at or before age 45 Invasive breast cancer diagnosed at/before age 50 with one or more of the following:
  • Limited family history (Fewer than 2 first- or second-degree female relatives in the same lineage that lived to age 45. The "limited family history" can occur on either the maternal or paternal side of the family.)
  • 1 or more first-/second-degree relatives with invasive BC at/before 50
  • 1 or more first-/second-degree relatives with invasive epithelial ovarian cancer (any age)
  • 1 or more first- or second-degree relatives with male breast cancer
  • 2 or more first- or second-degree relatives with pancreas cancer
  • Invasive breast cancer diagnosed at or before age 60 with at least 2 first or second-degree relatives affected with any combination of invasive breast cancer before age 50, invasive epithelial ovarian cancer at any age, male breast cancer, or pancreas cancer.
  • Full sequence BRCA1 and BRCA2 testing completed with no deleterious mutation identified.

Exclusion criteria

  • Unable to provide informed consent for testing
  • Unable to complete English language questionnaire

Trial design

197 participants in 1 patient group

history of breast cancer who have undergone BRCA1/2 testing
Description:
This is a single-arm observational study. Subjects with a history of breast cancer who have undergone BRCA1/2 testing and have received uninformative findings will enroll in this study, and then receive pre-test counseling for multiplex testing.
Treatment:
Other: Blood draw
Behavioral: Pre test Counseling
Behavioral: Pre-test Assessment
Behavioral: Post-test counseling, and post-test assessment
Behavioral: Follow-up assessments (6 and 12 months)

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems