Multisensory Body and Space Representations (BASES-EXTINCTION)
Status
Unknown
Conditions
Healthy
Blindness
Treatments
Other: MRI
Other: MEG
Other: Changes in skin temperature
Other: Electrodermal response
Other: Transcranial electrical stimulation in direct current (tDCS)
Other: Transcranial magnetic stimulation (TMS)
Other: Surface Electromyography (EMG)
Other: Electrooculogram (EOG)
Details and patient eligibility
About
To accurately control body movements to interact with objects, our brain needs representations of the body and the nearby space. The broader aim of this research project is to study the behavioural and physiological mechanisms involved in the constitution of these representations, to identify their neural bases, in order to better understand the dysfunctions in the context of neurological or developmental disorders.
Enrollment
1,540 estimated patients
Sex
All
Ages
5 to 71 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- Male or female aged 5 to 71
- Subject affiliated to the general social security scheme or a similar scheme
- Subject agreeing to participate in the study with informed consent -Capable of understanding information and simple instructions related to the study
Exclusion criteria
- Subject under tutelage or guardianship- Subject under tutelage or guardianship
- Subject not able to give informed consent, unable to receive information about the study
- Subject not affiliated to a French or non-French social security system holder of a European health insurance card
Trial design
Primary purpose
Basic Science
Allocation
Non-Randomized
Interventional model
Parallel Assignment
Masking
None (Open label)
1,540 participants in 5 patient groups
Behavioral protocol
Other group
Description:
To better understand the normal functioning of the brain within the framework of the representation of the body and of the space of action. During the experiment, physiological measurements will be recorded: electrical activity at the surface of the muscles (electromyography - EMG), scalp (electroencephalography - EEG) or skin (electrodermal response). Similarly, the movements of the arm will be recorded using an infrared kinematic system requiring simply the placement of markers at strategic points such as the tip of the thumb and forefinger, the wrist, the elbow ... Movements of the eyes can also be recorded, either with the aid of an electrooculograph (EOG) or with the aid of an infrared tracking device. Electrotactile stimulations of very low intensity and painless can also be administered.
Treatment:
Other: Electrooculogram (EOG)
Other: Changes in skin temperature
Other: Surface Electromyography (EMG)
Other: Electrodermal response
Study in fMRI
Other group
Description:
To better understand the normal functioning of the brain in the representation of the body and the space of action, to identify the brain areas critical for these functions and to determine their functional roles. The examination will consist of several very short scans at the very beginning and then a scan of about ten minutes intended to take a detailed anatomical image of the brain. Then, the subject will carry out the experimental task during one or more scan (s) whose cumulative duration will not exceed 45 minutes. The task accomplished is explained in detail by the experimenter.
Treatment:
Other: MRI
Study in MEG
Other group
Description:
To better understand the normal functioning of the brain in the representation of the body and the space of action, to identify the critical brain areas for these functions and to determine their functional roles and to study how They interact.The complete examination includes a magnetoencephalography (MEG) experiment followed by an MRI examination. The task accomplished is explained in detail by the experimenter.
Treatment:
Other: MRI
Other: MEG
Study in TMS
Other group
Description:
To better understand the normal functioning of the brain in the representation of the body and the space of action, to determine the functional role of the brain areas involved in these processes. Before the Transcranial magnetic stimulation (TMS) examination, MRI of the brain will be performed.The TMS review will consist of three distinct sessions separated from one another by at least one week, depending on the protocol, and which will differ simply at the site or type of stimulation.
Treatment:
Other: MRI
Other: Transcranial magnetic stimulation (TMS)
Study in tDCS
Other group
Description:
To better understand the normal functioning of the brain in the representation of the body and the space of action, to determine the functional role of the cerebral areas involved in these processes. The transcranial Direct Current Stimulation (tDCS) exam will consist of three separate sessions separated from each other by at least one week and will simply differ at the stimulation site. The task accomplished is explained in detail by the experimenter.
Treatment:
Other: Transcranial electrical stimulation in direct current (tDCS)
Trial contacts and locations
1
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Central trial contact
Alessandro FARNE, PhD; Gilles RODE, MD
Data sourced from clinicaltrials.gov
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