Multisensory Processing of Alcohol Cues in Young Adult Binge Drinkers

Rochester Institute of Technology

Status: Not yet enrolling

Conditions: Drinking, Binge

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT06885190

SRS00020124

R15AA031579-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Binge drinking is common among young adults and is related to many negative health outcomes including blackouts, risky sex, drunk driving, alcohol use disorder, and liver disease. Understanding whether there are differences in how binge drinkers respond to alcohol-related cues and whether this is related to craving is important for improving interventions and treatments. The proposed study will compare behavioral and neural processing of alcohol and non-alcohol cues in a single sensory modality (vision) with that of cues presented in multiple sensory modalities (vision, touch, and smell) with varying degrees of realistic appearance (images, virtual reality, real objects). Participants will answer questionnaires related to their physical and mental health and recent alcohol and drug use. Those eligible for the study will complete two in-person lab sessions. During both sessions they will be asked to view a series of cues which will include images on a computer screen, objects presented in virtual reality, or real objects. Sometimes these will be presented just visually and other times they will be combined with the presentation of specific smells or an object to touch. Some of these cues will be alcohol-related and others will be neutral (non-alcohol-related). Brainwave activity, as measured by the electroencephalogram (EEG), and reports of alcohol craving will be collected during these sessions. It is expected that brainwave activity will be greatest in response to multisensory cues compared to that in response unisensory (visual only) cues. It is also expected that young adults with a recent history of binge drinking will show the greatest brainwave activity in response to multisensory alcohol cues compared to social drinkers. Binge drinkers will also report more alcohol craving in response to multisensory alcohol cues compared to social drinkers. It is anticipated that brainwave responses will increase as the level of realism of the cues increases. Binge drinkers will also show stronger brainwave and craving responses to multisensory alcohol cues presented as real objects. Finally, binge drinkers will show lessened brain and craving responses when multisensory cues do not match compared to social drinkers. For example, if a photo shows an alcoholic drink but the smell presented is not alcohol related, binge drinkers will show less attentive brain activity toward those mismatched cues. Given that most alcohol cues in daily life are experienced across multiple senses simultaneously, results of this research will provide a better understanding of the relation between alcohol cue processing and craving, and will inform development of more effective programs for decreasing young adult risky drinking behavior.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ages 18 to 25 years old
• meet criteria for either the binge drinker or social drinker groups previously described

Exclusion criteria

• history of head injury involving loss of consciousness of 10+ minutes
• colorblindness
• hearing, tactile, olfactory or uncorrected vision deficits
• history of seizures
• neurological disorder diagnosis
• mental health history of psychosis or mania
• history of alcohol or substance use disorder diagnosis
• illicit drug use in the past 30 days
• changes to psychotropic medication type or dose in past 3 months

Trial design

100 participants in 2 patient groups

Young Adult Binge Drinkers

Description:

Participants ages 18 to 25 with a history of binge drinking (at least 2 episodes of 5+ standard drinks per episode for males/4+ standard drinks per episode for females) in the past month and at least 4+/3+ (males/females) score on the Alcohol Use Disorder Identification Test.

Young Adult Social Drinkers

Description:

Participants ages 18 to 25 who report drinking alcohol at least once in the past month but no current history of a binge pattern (i.e., 2 or fewer drinks per episode) AND score less than 4/3 (males/females) on the Alcohol Use Disorder Identification Test.