Multivariate Analysis and Machine Learning Model Risk Prediction of Recurrent Pain After PLIF Surgery for Degenerative Lumbar Spine Disease At Long-term Follow-up

Hao Liu

Status: Completed

Conditions: Lumbar Degenerative Disease; Lumbar Disc Herniation; Sarcopenia

Treatments: Other: MRI with Eovist

Study type: Observational

Funder types: Other

Identifiers

NCT06622356

(2024) Lun Yan Grant No. 517 (Other Identifier)

Details and patient eligibility

About

The study was a clinical retrospective study designed to investigate risk factors for long-term recurrent pain after PLIF in patients with lumbar degenerative disease and to improve patient outcomes

Enrollment: 452 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. confirmed diagnosis of lumbar degenerative disease (spinal stenosis, disc herniation with lumbar instability, and lumbar spondylolisthesis), with no significant symptomatic relief after conservative treatment for more than 3 months, and in need of surgical intervention;
2. lumbar spinal fusion surgical treatment with PLIF;
3. grouping based on the presence or absence of a lumbar or limb pain with VAS ≥3 at the 12-18 month postoperative follow-up;
4. observational indicators including individual factors, surgical factors, spine-pelvis sagittal balance parameters, and paravertebral muscle parameters.

Exclusion criteria

(1) those with a history of lumbar spine trauma, inflammation, tumor, or surgery; (2) those with congenital or acquired severe lumbar vertebral deformity; (3) those with severe neurological dysfunction; (4) those with incomplete baseline and follow-up data.

Trial design

452 participants in 2 patient groups

Rehabilitation Group

Description:

Rehabilitation Group (n = 268): mild/non pain group with VAS\<3 at 12-18 months after PLIF。The study was retrospective and did not design an intervention

Treatment:

Other: MRI with Eovist

Recurrent pain group

Description:

Recurrent pain group (n = 184): recurrent pain group with VAS≥3 at 12-18 months after PLIF

Treatment:

Other: MRI with Eovist