Muscle Function After Intensive Care

University of Liege

Status: Completed

Conditions: Muscle Strength; Healthy; Critically Ill; Colorectal Surgery

Treatments: Other: Patient follow up

Study type: Observational

Funder types: Other

Identifiers

NCT03922113

FAIC

Details and patient eligibility

About

Final objective of critical care is no longer only survival. The role of medical and paramedical teams should also be to restore functional capacities, autonomy and quality of life. What has been call "intensive care unit - acquired weakness" (ICU-AW) is associated to acute and long term increased mortality, prolonged ICU and hospital stay, prolonged duration of mechanical ventilation, altered quality of life in survivors and increased health-related costs. In order to target efficient secondary prevention and early rehabilitation, prompt identification of muscle weakness is crucial. Several methods, aiming to assess muscle mass, muscle strength or physical function, are described. Manual muscle testing using the Medical Research Council (MRC) scale is still the most commonly utilized tool to diagnose ICU-AW (MRC <48/60). Dynamometry is an objective alternative and one of the most accurate clinimetric tool to assess muscle strength. Literature is overflowing with insufficiently standardized dynamometry data. Using the investigator's published standardized protocol of quadriceps strength (QS) assessment, this observational study aim to describe physical performances of CC patients and thus to define the weakest ones, by comparing them to surgical and healthy subjects.

Enrollment: 104 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Collaborative ICU patients with length of stay > 48h
• Surgical patients scheduled for colorectal surgery
• Healthy subjects

Exclusion criteria

• a score > 1 or < -1 on the Richmond Agitation and Sedation Scale (RASS)
• coma
• total hip or knee arthroplasty in the dominant limb
• unauthorized support on the dominant leg
• open wound located at the ankle's anterior face of the dominant leg
• pre-existing myopathy or polyneuropathy
• para- or tetraparesis, para- or tetraplegia
• refusal.

Trial design

104 participants in 3 patient groups

Critically ill patients

Description:

Patients who spent a minimum of 48h in ICU

Treatment:

Other: Patient follow up

Surgical patients

Description:

Patients who were scheduled for elective colorectal surgery

Treatment:

Other: Patient follow up

Healthy subjects

Description:

Healthy volunteers

Treatment:

Other: Patient follow up