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Muscle Insulin Resistance in Aging (Mirage)

A

AdventHealth Translational Research Institute

Status

Active, not recruiting

Conditions

Insulin Resistance
Sarcopenia

Treatments

Behavioral: Energy Restriction-Induced Weight Loss
Behavioral: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT02230839
TRIMDFH 500423

Details and patient eligibility

About

The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.

Full description

Study Objectives:

  1. To determine the effects of diet-induced weight loss with and without the addition of exercise on mitochondrial biogenesis and energetic capacity, cellular redox state and insulin resistance.
  2. To determine the effects of diet-induced weight loss with and without the addition of exercise on intramyocellular lipid profiles.
  3. To determine the effects of diet-induced weight loss with and without exercise on skeletal muscle proteins mediating a program of autophagy and either loss or maintenance of muscle mass.

Enrollment

200 estimated patients

Sex

All

Ages

65 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 65-80 years of age
  • Stable weight (No Gain/Loss of >10 lbs in 6 months)
  • Sedentary (≤ 1 continuous exercise/week)
  • Non-smoker
  • BMI ≥ 30 kg/m2
  • Resting Blood Pressure ≤ 150 millimeters of mercury systolic and ≤ 95 millimeters of mercury diastolic
  • Note from Primary care physician/Cardiologist for exercise clearance if positive stress test symptoms were observed from exercise test
  • Must be willing to washout for 14 days from all diabetes medication and independent in self blood glucose monitoring during the washout periods (those with diabetes only)

Exclusion criteria

  • Clinically significant cardiovascular disease including history of myocardial infarction, within the past year
  • Peripheral Vascular Disease
  • Hepatic, renal, muscular/neuromuscular, or active hematologic/oncologic disease
  • Clinically diminished pulse
  • Presence of bruits in lower extremities
  • Previous history of pulmonary emboli
  • Peripheral Neuropathy

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

200 participants in 3 patient groups

Exercise training protocol
Experimental group
Treatment:
Behavioral: Exercise
Energy restriction-induced weight loss
Experimental group
Treatment:
Behavioral: Energy Restriction-Induced Weight Loss
Health Education
No Intervention group

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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