Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

David Travis Thomas

Status: Completed

Conditions: Vitamin D Deficiency

Treatments: Other: 7 continuous days of aerobic training

Study type: Interventional

Funder types: Other

Identifiers

NCT02485197

12-1029-F6A

Details and patient eligibility

About

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

Enrollment: 7 patients

Sex: All

Ages: 65 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 65-75 years of age

Exclusion criteria

• Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
• Uncontrolled diabetes or hypertension.
• History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
• History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
• Have a diagnosis of osteoporosis (as determined by DXA)
• Participated in a resistance or aerobic training program in the last 3 months
• Engage in more than 1 hr/week of vigorous activity
• Body mass index >29
• On hormone replacement therapy

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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7 participants in 2 patient groups

Low 25(OH)D

Other group

Description:

We will recruit individuals with low 25(OH)D (\<30ng/mL).

Treatment:

Other: 7 continuous days of aerobic training

High 25(OH)D

Other group

Description:

We will recruit individuals with higher 25(OH)D (at least 20ng/mL units higher then that of the "low 25(OH)D group).

Treatment:

Other: 7 continuous days of aerobic training